Assessment of the DTI?ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia

BACKGROUND AND PURPOSE: Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for central nervous and its role flushing solutes (such as amyloid s tau), metabolic, other cellular products brain. Herein, we investigate a recent potential biomarker activity diffusion tensor imaging along perivascular space [DTI-ALPS] parameter) using MRI an elderly cohort comprising 10 cognitively normal, mild cognitive impairment (MCI), 16 Alzheimer's disease (AD). METHODS: All 36 participants imaged on Siemens 3.0T Tim Trio. Single-SE weighted Echo-planar scans were acquired well T1 magnetization prepared rapid gradient echo, T2 axial, susceptibility imaging. Three millimeter regions of drawn projection association fibers adjacent to medullary veins at level lateral ventricle. The DTI-ALPS parameter was calculated these correlated with status, Mini-Mental State Examination (MMSE), ADASCog11 measures. RESULTS: Significant correlations found between MMSE right hemisphere adjusting age, sex, APoE e4 status. differences also indices normal AD groups (P < .026) MCI .025) univariate general linear model corrected e4. apparent coefficient = .028). CONCLUSION: Further work is needed determine utility index larger cohorts whether it measures activity.